We report here on experimental and theoretical efforts to determine how best to combine drugs that inhibit HER2 and AKT in HER2(+) breast cancers.We accomplished this by measuring cellular and molecular responses to lapatinib and the AKT inhibitors (AKTi) GSK690693 and GSK2141795 in a panel of 22 HER2(+) breast cancer cell sheepshead bay boats line
Gossypiboma is a rare condition caused by retention of a foreign body, most commonly surgical sponge following any surgical procedure.The patient may be asymptomatic, can present with vague symptoms, or rarely with acute symptoms depending on the location of the click here foreign body and the complications associated with it; thus it may be diffic
The study of Swazi historical affairs in the colonial period has remained patchy.The historian is confronted by numerous gaps that make it difficult to get a comprehensive view of the development of the history of the country during this period.One of the neglected subjects is the nature el reformador tequila anejo of the relations between indigeno
The urgency of global ecological issues is becoming increasingly critical, with political frameworks playing a pivotal role in addressing these challenges.This paper explores the political dimensions of global ecological governance, focusing on how international agreements and national policies intersect to shape sustainable environmental outcomes.